Thrombolytic therapy for peripheral vascular disease
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منابع مشابه
Thrombolytic therapy in peripheral vascular disease.
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Pearls 1. Patient workup and evaluation is key to a successful intervention while limiting complications. In addition to physical exam and laboratory evaluation, review of prior imaging studies and surgical interventions is important to understanding the etiology of the occlusion and to guide therapy. 2. Use of arterial thrombolysis should be avoided in patients with evidence of irreversible li...
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Several studies since 1998 have shown the efficacy of catheter-directed thrombolytic therapy with reteplase. Reteplase is a plasminogen activator that penetrates the thrombus and causes lysis. This catheter-directed approach has been used to treat both arterial and venous occlusions, with a success rate of 72% to 88%. The most serious complication associated with thrombolytic therapy is intracr...
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Intraarterial thrombolytic therapy with urokinase (UK) offers documented advantages to alternatives for treating both subacute and the initial presentation of acute peripheral arterial occlusion (PAO), including reduced morbidity and mortality. Treatment with intraarterial UK does not increase overall health care costs; hospital length of stay is either similar to that with other therapies (acu...
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Prognosis of peripheral artery disease (PAD), especially critical limb ischemia, is very poor despite the development of endovascular therapy and bypass surgery. Many patients result in leg amputation and, therefore, vascular regenerative therapy is expected in this field. Gene therapy using vascular endothelial growth factor is the first step of vascular regenerative therapy, but did not confi...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 1995
ISSN: 0741-5214
DOI: 10.1016/s0741-5214(95)70102-8